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Titre de la Présentation :
How perfect can protein interactomes be?
Date / Heure / Emplacement:
Jeudi, 12 novembre 2009 – 18:00
McGill University
Salle 232, Édifice Leacock
855 Sherbrooke Ouest
Affiliation :
Université Laval
URL
Christian Landry
Abstract :
Evolutionary theory tells us that biological systems need not be optimized and may very well accumulate nonfunctional elements. Mutational and demographic processes contribute to the cluttering of eukaryotic genomes and transcriptional networks with « junk » DNA and spurious DNA binding sites. Here, I question whether such a notion should be applied to protein interactomes- that is, whether these protein interactomes are expected to contain a fraction of nonselected, nonfunctional protein-protein interactions. I discuss evidence for the existence of these non-functional interactions in kinase-substrate networks from the analysis of the evolution of phosphoproteomes of mammals and fungi.