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 Marie-Pierre Dubé

Talk Title :
Pharmacogenomics of warfarin: beyond dose prediction

Date / Time / Location:
Thursday April 12th, 2012 – 4:00 pm
Room S1-151 at IRIC

Affiliation :
StatGen

URL :
Marie-Pierre Dubé

Abstract :
Warfarin is the most widely used medication to treat blood clots and to prevent new clots from forming. Unfortunately, it is also associated with serious bleeding that can lead to hospitalization and death. Despite recent advances in our ability to use genetics to predict a patient’s optimal warfarin therapeutic dose, a significant portion of patients still experience wide fluctuations in their monitoring results during long term therapy with warfarin. The present talk will present the strategies used by our group to find predictive genetic signatures of unstable warfarin test results associated with higher risk of bleeding.