Michael Hallett

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Titre de la Présentation :
The Breast Cancer Tumor Microenvironment

Date / Heure / Emplacement:
Jeudi, 13 Novembre 2008 – 18:00
Salle S1-151 de l’IRIC

Affiliation :
McGill Center for Bioinformatics

Michael Hallett

Abstract :
It is increasingly evident that breast cancer outcome is strongly influenced by signals emanating from tumor-associated stroma. However, little is known about how gene expression changes in this tissue affect tumor progression. In this talk, we compare gene expression profiles from laser capture-microdissected tumor-associated versus matched normal stroma, and derive transcriptional profiles strongly associated with clinical outcome. We present a stroma-derived predictor that generates new information to stratify disease endpoint, independent of standard clinical prognostic factors and previously published predictors.

Genes represented in the stroma-derived predictor reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses. The computational and statistical aspects underpinning this work are built upon a new approach to analyzing gene expression data that in some sense is « orthologonal » to traditional clustering based tools, and is general in the sense that a wide range of data types can be easily integrated into the system.We show how this tool stratifies patients in an interesting and clinically relevant way.


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